Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.

نویسندگان

  • Romano Silvestri
  • Gabriella Marfè
  • Marino Artico
  • Giuseppe La Regina
  • Antonio Lavecchia
  • Ettore Novellino
  • Emanuela Morgante
  • Carla Di Stefano
  • Gianfranco Catalano
  • Giuseppe Filomeni
  • Elisabetta Abruzzese
  • Maria Rosa Ciriolo
  • Matteo Antonio Russo
  • Sergio Amadori
  • Roberto Cirilli
  • Francesco La Torre
  • Paola Sinibaldi Salimei
چکیده

Pyrrolo[1,2-b][1,2,5]benzothiadiazepine 5,5-dioxides (PBTDs) induced apoptosis in human BCR-ABL-expressing leukemia cells. The apoptotic activity was also observed in primary leukemic blasts, obtained from chronic myelogenous leukemia (CML) patients at onset or from patients in blast crisis and who were imatinib-resistant. Compounds 5 and 14 induced apoptosis before BCR-ABL protein expression and tyrosin phosphorylation were affected and activated different caspases in the apoptotic pathway. PBTDs are a new class of valid candidates for the treatment of CML.

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عنوان ژورنال:
  • Journal of medicinal chemistry

دوره 49 19  شماره 

صفحات  -

تاریخ انتشار 2006